It is important to use the medication we are prescribing for your pet. If you have concerns about anything you find on here, please contact our office at 518-446-9171 before stopping the medication.
What is “Mirtazapine”, also known as Mirataz?
Mirtazapine is a tetracyclic antidepressant used to appetite loss and nausea
How is “Mirtazapine” given?
It should be given orally or transdermally as directed
What if I miss giving my pet the medication?
We recommend waiting to give your pet their next dose at their next scheduled time. Please give us a call if you have any concerns and need clarification.
Are there any potential side effects?
- Application site reactions of the transdermal formulation can occur in cats
- Behavioral changes (vocalization, hyperactivity, disorientation, lethargy, attention seeking, aggression)
- Vomiting, polyuria associated with reduced specific gravity, elevated BUN, and dehydration
- Diarrhea, heart murmur, inappetence, renal insufficiency, ear infection, urinary tract infection, hematuria, elevated creatinine, hyperphosphatemia, hypokalemia, pyuria, anemia, low urine specific gravity, monocytosis, neutrophilia
- Muscle twitching, hyperactivity, vocalization, behavioral changes were reported with tablets
- Elevated ALT
Are there any risk factors for this medication?
- Contraindicated with cyproheptadine, tramadol, or monoamine oxidase inhibitors (MAOIs) as there is increased risk of serotonin syndrome
- Higher PO doses in cats (e.g., 3.75 mg per cat PO q 24 hr) were associated with increased adverse effects
- Use topical ointment with caution in cats with hepatic disease; may cause elevated serum liver enzymes
- Dose reduction of 25%–50% may be necessary if renal failure is present, as kidney disease may result in reduced mirtazapine clearance and cumulative toxicosis
- Pupillary dilation may occur which may trigger angle closure attack in patients predisposed to narrow angle glaucoma
- Discontinuation symptoms (dizziness, sensory disturbances, agitation, anxiety, tremor, nausea, vomiting) have been reported in humans following abrupt withdrawal of mirtazapine; gradual withdrawal is recommended for patients that have been receiving mirtazapine on a chronic basis
Are there any drug interactions I should be aware of?
- Concurrent use with cyproheptadine may negate effects of both drugs
- Increased risk of serotonin syndrome when administered concurrently with serotonergic drugs
- Drugs that inhibit cytochrome P450s and have caused 40–50% increased plasma levels of mirtazapine when coadministered in humans include cimetidine and ketoconazole
• Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.
Is there any monitoring that needs to be done with this medication?
No monitoring is necessary
How do I store “Mirtazapine”?
Keep in a tight container protected from light and moisture at room temperature
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately a href=”tel:518-446-9171″>(518-446-9171). If they are not available, follow their directions in contacting an emergency facility.